Technology & Infrastructure
CBIB houses an integrated ecosystem of supercomputing hardware, biophysical calorimetry, bioreactors, electron microscopy, and analytical chemistry platforms.
High-Performance Computational Biology Laboratory
Dedicated Precision-Cooled Server Room & Supercomputing Cluster
Our facility comprises more than eight high-performance servers configured with multiple CPUs and GPUs for intensive computational biology workloads:
- • CPUs: 2x Intel Xeon Ice Lake Platinum 8380 (XCC) (80 Cores / 160 Threads)
- • GPUs: 10x NVIDIA RTX 6000 Ada Generation
- • RAM: 4 TB High-Speed System Memory
- • CPUs: 2x AMD EPYC Milan 7763 (128 Cores / 256 Threads)
- • RAM: 4 TB High-Speed System Memory
- • Workloads: Genomics & Systems Biology
Bioreactor Systems & Fermentation Facility
Microbial Fermentation, Recombinant Protein Expression & Metabolic Engineering
0.5 – 6 L Fermentation Vessel
Minifors 2 Bioreactor Modular Benchtop
Compact, modular benchtop bioreactor designed for microbial fermentation, enzyme production, and protein expression. Features integrated software control for pH, dissolved oxygen ($dO_2$), temperature, and agitation rate.
1 – 10 L Scale-Up Fermentation
Labfors 5 Advanced Bioprocess System Industrial PAT
Advanced benchtop fermenter optimized for therapeutic protein production, metabolic engineering, and preclinical biomanufacturing. Equipped with Process Analytical Technology (PAT) and automated data logging.
Biophysical Calorimetry & Protein Purification Platform
Octet R4 BLI, ÄKTA Go FPLC, Nano-ITC & Nano-DSC
Octet R4 BLI System (Sartorius / FONDEQUIP)
4-channel Biolayer Interferometry (BLI) system for real-time label-free molecular interaction kinetics, antibody titering, and affinity ($K_d$) characterization. (Awarded by Dra. Valeria Márquez).
ÄKTA Go FPLC & TFF Filtration
Compact protein purification chromatography system (Cytiva) complemented by Tangential Flow Filtration (TFF) and refrigerated high-volume centrifuges (up to 4,000 mL per cycle) for large-scale nanobody & protein production.
Nano-ITC & Nano-DSC Calorimetry
Low-volume Isothermal Titration Calorimeter (190 µL) & Nano-DSC for label-free binding thermodynamics ($\Delta H, \Delta S$), stoichiometry, and thermal transition stability ($T_m$).
Analytical Chemistry, Microscopy & Nanomaterial Suite
Chromatography, Particle Sizing, Mass Spectrometry & BSL-2 Cell Culture
CO₂ Incubator for mammalian & bacterial cell lines, sterile laminar flow hoods, and transfection stations.
High-sensitivity fluorescence and luminescence detection in 96-well plate formats for enzyme and cell assays.
Agilent 1260 HPLC, GC/MS, Microwave Chemical Reactor, and Flame Atomic Absorption Spectrometer (FAAS) for metal quantification.
Dynamic Light Scattering (DLS) & Zeta potential analysis for nanoparticle size, surface tension, and contact angle.
Low-voltage TEM/SEM electron microscopy, Leica UC7 Ultramicrotome for ultrathin biological sample sectioning.
Nanobubble generator, sonicator, UV transilluminator, muffle furnace, drying ovens, and Heidolph™ magnetic stirrers.
Core Operations & Specialized Staff
CBIB facility operations are maintained by a dedicated team of specialists: System Administrator (Maximiliano Rojas), Bioinformatics Engineers, two Laboratory Managers, and Senior Researcher Dr. Alejandro Yévenes (20+ years of expertise in enzymology and protein characterization).